PRO-E0266
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More information| Catalogue No. | PRO-E0266 |
|---|---|
| EC | 4.2.2.1 |
| Synonyms | Hyaluronidase [but cf. EC 3.2.1.35 (hyalurononglucosaminidase) and EC 3.2.1.36 (hyaluronoglucuronidase)]; glucuronoglycosaminoglycan lyase; spreading factor; mucinase |
| Nomenclature | CAZy [PL16 | polysaccharide lyase family 16 (formerly known as GH69)] | HylP2 | hylP2 | SPy0997 |
| Specific Activity | 7.0 U/mg |
| Accession No. | Q99ZZ7 | NP_269179.1 | AAK33900 | SPYO160490:SPY0997-MON |
| Molecular Weight | 41975.3 Da |
| Biological Function | Cleaves hyaluronate chains at a ?-D-GalNAc-(1 4)-?-D-GlcA bond | ultimately breaking the polysaccharide down to 3-(4-deoxy-?-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine. HylP2 is a phage tail-fibre protein responsible for the digestion of the S. pyogenes hyaluronan capsule during phage infection. It is a key bacteriophage-encoded virulence factor |
| Comments | Phage associated. Active solely against hyaluronan with no activity against chondroitin 4-sulfate and chondroitin 6- sulfate |
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